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Epigenetic Modifications of Capecitabine

by janeausten

Epigenetic mechanisms are pathways involved in gene expression and regulation. These mechanisms can be modulated by drugs to alter gene expression and function, leading to improved outcomes or the prevention of disease. The epigenetic Capecitabine 500mg Tablet has been used in cancer treatment to regulate gene expression and boost the efficacy of drugs. By altering gene expression, Capecitabine can repress the growth of certain cancer cells and also activate certain cell types to support the growth of healthy cells.

Modified action of Capecitabine

Capecitabine tablet is a chemotherapy drug that acts by inhibiting the conversion of cytidine triphosphate (CTP) to dihydrofolate reductase (DFR), resulting in the depletion of thymidylate and incorporation of guanine into the DNA, and leading to DNA damage. The Capecitabine 500 mg tablet also binds directly to DNA, altering the transcription of certain genes. This drug is unique from other chemotherapy drugs because it is metabolized in the cytoplasm instead of the nucleus.

Epigenetic biomolecular modification of Capecitabine

The epigenetic effects of the Capecitabine tablet are mediated through its ability to modify the epigenome, resulting in altered gene expression. It causes an increase in the expression of the gene myeloid differentiation factor 88, promoting a decrease in interferon-gamma. This deactivates the expression of genes associated with cancer, causing a reduction in cancer cell growth. Additionally, Capecitabine can inhibit the enzyme histone deacetylase (HDAC), leading to gene activation. HDAC inhibition by Capecitabine can activate the stabilization of the tumor suppressor p53, leading to the inhibition of cancer cell proliferation.

Genetic effects of Capecitabine

Capecitabine can also affect the expression of certain genes related to DNA repair. It has been found to decrease the expression of the genes for excision repair cross-complementing and DNA repair enzymes. This decrease in the expression of DNA repair genes can lead to increased mutagenicity and therefore an increase in the rate of cell death due to DNA damage caused by Capecitabine.

Widespread use effect of Capecitabine

Capecitabine has widely used in the treatment of breast, colorectal, and gastric cancers due to its ability to inhibit tumor cell growth and DNA damage. It has also been found to play a role in inducing immunogenic cell death, leading to the activation of innate and adaptive immune pathways which can be beneficial for tumor immunotherapy.

Capecitabine tablet price

The Capecitabine 500mg Price can vary depending on where you buy them and the dosage you need. Generally, the price of Capecitabine 500mg tablets ranges f depending on the pharmacy and Capecitabine dose

In summary,

Capecitabine is an epigenetic drug that affects gene expression through its ability to modify the epigenome. It can inhibit tumor cell growth by both decreasing the expression of certain genes associated with cancer and increasing the expression of the gene myeloid differentiation factor 88. Additionally, Capecitabine can inhibit DNA repair pathways and activate the tumor suppressor p53. Through its various epigenetic effects, Capecitabine can repress the growth of certain cancer cells and increase the efficacy of other drugs. It is widely used in cancer treatment

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