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How to deal with drug addiction

by janeausten
How to deal with drug addiction

Disulfiram, on the other hand, How to deal with drug addiction is a second-line treatment with many contraindications and delicate handling, reserved for patients who have failed with previous treatments and benefit from support from those around them.

Acamprosate

Acamprosate acts on GABAergic activity and antagonizes the action of excitatory amino acids, that of glutamate. It corrects neuronal hyper-excitability and regulates mesolimbic dopaminergic activity (reward circuit, involved in all addictive phenomena).

It is indicates in any form of alcohol dependence, upon stopping alcohol. The only contraindications are breast-feeding and renal insufficiency (exclusive elimination and in unchanged form at the renal level).

It is a second-line treatment, for patients in great difficulty with alcohol and who have failed with first-line treatment involving Acamprosate or Naltrexone. The contraindications are indeed multiple because of the effects associated with the simultaneous intake of alcohol (with a maximum of collapse, sudden death, arrhythmias, angina, respiratory depression, neurological accidents), undesirable effects and drug interactions. confusional states), Phenytoin ( significant and rapid increase in plasma levels with toxic signs linked to an inhibition of its metabolism) but also (combination subject to precautions for use) with Warfarin, and by extrapolation of other anticoagulants, resulting in an increase in the effect oral anticoagulant by decreased hepatic metabolism

There is no drug therapy interaction or specific clinical or biological monitoring to offer.

The high frequency of digestive disorders justifies informing patients in advance of their possible occurrence, at the risk of spontaneous interruption of treatment.

Naltrexone

Naltrexone is a mu opioid receptor antagonist. It would act in alcohol-dependent subjects by promoting the regulation of mesolimbic dopaminergic activity.

Naltrexone is indicates in all forms of alcohol dependence to prevent relapse, except in subjects with opioid-associates dependence due to its opioid antagonist profile. Its effect of preventing massive alcohol consumption could make it preferable in subjects with a strong psychological dependence.

It is contraindicates in subjects with severe hepatocellular impairment (hepatic metabolism) and those with opioid-associates dependence or opioid replacement therapy.

The dosage is one tablet per day.

The main side effects noted are nausea and / or vomiting, headache, sedation or insomnia, anxiety, nervousness, abdominal cramps and pain, joint and muscle pain.

The main interactions concern on the one hand the opioid antagonist effect (opioid analgesics and opioid substitution treatments) with loss of efficacy of analgesics and withdrawal-induced in subjects dependent on opiates, alcohol rehab near me, and on the other hand the sedative effect with potentiation. effects of other Central Nervous System depressants. There is no reported interaction with hepatitis C treatments and in particular protease inhibitors.

The recommended duration of treatment is 3 months, and its daily cost is 1.30 euros.

Disulfiram

It is an aversive treatment, causing a violent physiological reaction during alcohol consumption, dissuasive in alcohol-dependent subjects. Inhibits acetaldehyde dehydrogenase, and causes an increase in the concentration of acetaldehyde, a metabolite of ethyl alcohol responsible for unpleasant manifestations: flushing of the face, nausea, and vomiting, feeling of malaise, tachycardia, hypotension.

The efficacy of effects has been the subject of only a few early studies and with limited methodology. The main results show that when taking the health is supervise, it has an effect on short-term abstinence, the number of days before relapse and the number of days of alcohol consumption. Its effectiveness has also been explores in the context of cocaine addiction, but without conclusive results so far.

Health issues

It is a second-line treatment, for patients in great difficulty with alcohol and who have failed with first-line treatment involving Acamprosate or Naltrexone. The contraindications are indeed multiple because of the effects associated with the simultaneous intake of alcohol (with a maximum of collapse, sudden death, arrhythmias, angina, respiratory depression, neurological accidents), undesirable effects and drug interactions. confusional states), Phenytoin ( significant and rapid increase in plasma levels with toxic signs linked to an inhibition of its metabolism) but also (combination subject to precautions for use) with Warfarin, and by extrapolation of other anticoagulants, resulting in an increase in the effect oral anticoagulant by decreased hepatic metabolism.

In practice, small amounts of alcohol can trigger an aversive reaction and the patient should be inform. The alcohol contained in the methadone solution is not, however, a priori sufficient to trigger the anti-abuse reaction. It is necessary to wait at least 24 hours after the last alcohol intake before taking for the first time and an Antabuse reaction may occur when taking alcohol for up to 2 weeks after stopping it. The treatment will be starts at a dosage of half (to assess tolerance) then one tablet per day thereafter, in the morning.

Good Rehab drug addiction Services

It is a second-line treatment, for patients in great difficulty with alcohol and who have failed with first-line treatment involving Acamprosate or Naltrexone. The contraindications are indeed multiple because of the effects associated with the simultaneous intake of alcohol (with a maximum of collapse, sudden death, arrhythmias, angina, respiratory depression, neurological accidents), undesirable effects and drug interactions. confusional states), Phenytoin ( significant and rapid increase in plasma levels with toxic signs linked to an inhibition of its metabolism) but also (combination subject to precautions for use) with Warfarin, and by extrapolation of other anticoagulants, resulting in an increase in the effect oral anticoagulant by decreased hepatic metabolism

interacts (associations not recommended) with Isoniazid (behavioral and coordination disorders), Nitro-5-imidazoles (metronidazole, ornidazole, secnidazole, tinidazole: observation of delusional flushes.

Rehab services and Alcohol addiction

confusional states), Phenytoin ( significant and rapid increase in plasma levels with toxic signs linked to an inhibition of its metabolism) but also (combination subject to precautions for use) with Warfarin, and by extrapolation of other anticoagulants, resulting in an increase in the effect oral anticoagulant by decreased hepatic metabolism.

Adverse effects should also be considers. They can be gastrointestinal (changes in taste and breath, nausea, gastralgia, diarrhea), hepatic (elevation of transaminases), neurological (polyneuritis, optic neuritis, headache, drowsiness, neuropsychic disorders such as memory disorders or confusion.).

In conclusion, the importance of contraindications and undesirable effects may seem prohibitive and discourage the prescription of these rehab centers near me. However, it appears that when “everything” has failed, it is only thanks to that some patients are able to stop their alcohol consumption. The support of those around him is however essential when prescribing it and a meeting with relatives is strongly recommends for the success of the care.

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